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Mutant SOD1 proteins can form toxic aggregates and lose their enzymatic activity, leading to increased oxidative stress [168]

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RSH + GSSG RSSG + GSH Glutathionylation is common in the cytosol and mitochondria

Moderation is key to preserving these levels

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The ratio of GSH:GSSG (glutathione redox ratio) is a sensitive index of oxidative stress, which can lead to a toxic imbalance between the production and removal of reactive oxygen species (ROS)