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At 3 DPI, biosynthetic processes of carbon-mediated metabolism, cell structure formation, amino acid metabolism and secondary metabolite biosynthesis were mostly enriched, indicating fast metabolic changes in the fungal cells (Fig

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Selenite is reduced to selenide (Se 2 ) by sulphite reductase (Figure 2, step 3), and then it is transformed to selenocysteine (SeCys) by O-acetylserine thiol-lyase (Figure 2, step 4)

Notably, these biomarkers are not solely metabolic but also reflect chronic inflammatory and immunometabolic stress (for example, oxidative stress, impaired mitochondrial health and immunoendocrine signaling)

Instead, we propose to examine how such factors work and to evaluate the reparative tools generously provided by nature. We used two approaches to address these objectives