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Any specific decimal-precision number cited without a human PK study should be treated as speculative

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Thyroid function tests (TSH, free T4) should be checked at baseline, 6-8 weeks after achieving maintenance dose of the weight loss medication, and every 3-6 months during active weight loss to ensure appropriate thyroid hormone replacement

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They're metabolic medications whose weight effect is one of several outcomes worth caring about, and probably not the most important one