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Glucagon-receptor agonism is the genuinely novel arm: while glucagon classically raises blood glucose, controlled glucagon-receptor activation also increases energy expenditure and drives hepatic fat oxidation, which is why the triple agonist produces such pronounced reductions in liver fat

Strictly adhering to the prescribed titration schedule is criticalpatients should not increase doses more rapidly than recommended, even if tolerating the current dose well, as this increases the risk of prolonged side effects

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When the stomach stretches or sends stronger vagal signals, the afferent side of the hiccup arc receives louder input

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