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The selenoprotein family of iodothyronine deiodinases consists of three enzymes, D1, D2 and D3, which are specifically distributed in tissues and regulate the activation and inactivation of TH: type 1 and 2 deiodinases (D1/D2) catalyse the conversion of the inactive precursor thyroxine (T4) to the active form, triiodothyronine (T3), while type 3 deiodinases (D3) terminate the hormones action by degradation ( 5 Hcy and thyroid diseases 5.1 Hcy and thyroid nodules In recent decades, with the widespread availability of ultrasound technology, thyroid nodules have become a common clinical disease

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Research suggests that HSCs typically constitute 5%8% of a healthy human liver, primarily regulating ECM synthesis and degradation to modulate hepatic sinusoidal blood supply (El-Serag, 2012)

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With pharmacological administration of GLP-1, this effect is, however, subject to rapid but incomplete desensitization (95, 96)

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