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Inhibiting IDH1 reduces damage and apoptosis in Ox-LDL-treated macrophages while increasing Nrf2 levels, thereby decreasing foam cell formation (Su et al., 2021)

With over 173,000 studies on PubMed, it's one of the most researched molecules for health and longevity

Good inflammation occurs when the immune system gears up to fight a pathogen, such as a bacteria or virus, but metabolic diseases, such as type 2 diabetes and obesity, involve unhealthy inflammation that can injure tissues

[DOI] [PubMed] [Google Scholar] 49.Hertzel AV, Smith LA, Berg AH, Cline GW, Shulman GI, et al

But efficacy is only one aspect of the clinical assessment of the retatrutide vs

doi:10.2337/diacare.27.11.2628