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Practitioners report that most patients begin noticing effects (reduced appetite, mild GI symptoms) somewhere between 1.0 and 2.0 mg per week, but this varies dramatically between individuals

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The choroidal glutathione-S-transferase enzymatic activity is increased following treatment of developing rats with dimethylfumarate GSTs form a multigenic family of GSH-conjugating isoenzymes

doi:10.3390/nu11092073 (accessible en ligne) 8 - Randomized controlled trial of oral glutathione supplementation on body stores of glutathione - Eur J Nutr

it doesn't override poor movement patterns

They may even stop glutathione production altogether