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Hippocampal insulin resistance impairs spatial learning and synaptic plasticity

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Rectal body temperature Conscious mice were restrained and a high-precision thermometer (BIO-TK8851, Bioseblab) was carefully inserted half-way into the rectum

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They belong to a class of compounds designed to interact with multiple hormone receptors involved in physiological regulation

Dosing protocol frameworks Dose escalation approach: Clinical trials employed gradual dose escalation to manage gastrointestinal tolerability