As serotonin has been shown to have critical functions in sleep (74), with disruption of the serotonergic system leading to short sleep duration and altered homeostatic sleep drive (75), urolithin A may improve sleep by stimulating the serotonergic system
pubmed.ncbi.nlm.nih.gov (peer-reviewed) [Note: Mouse model
This depends on the dose and frequency: 5mg vial: At 5mg 3x/week = less than 1 week (single dose per vial) At 5mg 2x/week = less than 1 week 10mg vial: At 5mg 3x/week = ~2.3 days (2 doses per vial) At 5mg 2x/week = 3.5 days (2 doses per vial) At 10mg 2x/week = 1 dose per vial MOTS-C is consumed faster than most peptides due to the higher per-dose amounts
The primary one is practical: if tirzepatide makes you nauseous, you can sleep through the worst of it
Comparatively, a study by Li et al
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