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Given the relatively smaller reduction in body weight (9.4%) in the SELECT trial compared to previous RCTs: 14.9% in STEP1 (BMI 37.86.7 kg/m 2 ) [16] and 13.2% STEP6 (BMI 31.9 kg/m 2 ) [49], pleiotropic effects of semaglutide may contribute to the overall CV risk reduction [25,37]

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When a practice spends a large portion of its time managing GLP-1 titration, side effects, adherence issues, and dietitian-guided follow-up, that focus can improve the day-to-day patient experience for straightforward obesity treatment

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Structure Therapeutics Today GPCR Structure Therapeutics $49.12 -1.68 (-3.31%) As of 07/24/2026 04:00 PM Eastern 52-Week Range $15.80 $94.90 Price Target $110.55 The company has more recently followed the trend toward GLP-1 drugs as well, and its aleniglipron has recently demonstrated 16.3% weight loss, adjusted for certain trial factors, and could beat out some competitors in terms of safety and manufacturing costs

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2020 Oct;90(5-6):514-526

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Funding This work was funded by the Natural Sciences and Engineering Research Council of Canada (NSERC, Discovery grant nos

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