In the US, it's not FDA-approved but legal to possess for research
beyond that trial and the halted Phase 2 lipodystrophy study, there are no completed human trials measuring body composition, strength, or long-term safety outcomes, so evidence for bodybuilding-related benefit claims remains preliminary and largely extrapolated from the hormone's known biology rather than from direct testing of CJC-1295
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Biochem Biophys Res Commun 485(2):440445 Doglioni G, Fernndez-Garca J, Igelmann S, Altea-Manzano P, Blomme A, La Rovere R, Liu XZ, Liu Y, Tricot T, Nobis M, An N, Leclercq M, El Kharraz S, Karras P, Hsieh YH, Solari FA, Martins Nascentes Melo L, Allies G, Scopelliti A, Rossi M, Vermeire I, Broekaert D, Ferreira Campos AM, Neven P, Maetens M, Van Baelen K, Alkan HF, Planque M, Floris G, Sickmann A, Tasdogan A, Marine JC, Scheele C, Desmedt C, Bultynck G, Close P, Fendt SM (2025) Aspartate signalling drives lung metastasis via alternative translation
The researchers concluded that obesity has unique neurobiological aspects in the reward circuitry, resembling opioid addiction more than other addictive disorders
This systemic effect simply cannot occur with topical application
