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Guidelines on the diagnosis and treatment of male infertility

Riboflavin status, measured by the functional biomarker erythrocyte glutathione reductase coefficient (EGRac), has been found to decrease only marginally, up to 10 % during pregnancy, however this was reported to occur together with a progressive increase in the prevalence of riboflavin deficiency, especially towards the end of the third trimester (Reference Heller, Salkeld and Krner63Reference Bates, Prentice and Paul65)