Nat Genet (2018) 50(5):6938
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The -cells secrete GABA along with insulin and the GABA binds to GABA receptors on the neighboring islet alpha cells (-cells) and inhibits them from secreting glucagon (which would counteract insulin's effects)
This selectivity makes FOXO4-DRI valuable for tissue engineering applications where elimination of senescent cells from expanded cell populations could improve research outcomes and provide researchers with enhanced cell preparation methods for regenerative medicine investigations
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