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Pharmacotherapy Obesity pharmacotherapy has recently experienced a revolution with the advent of glucagon-like-peptide (GLP)-1 agonists (for example, semaglutide), and subsequently multi-incretin receptor agonists including dual agonists (for example, gastric inhibitory polypeptide (GIP) analogue and a GLP-1 receptor agonist, Tirzepatide) and triple agonists (for example, GLP-1, GIP, and glucagon receptor (GCGR), Retatrutide)

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