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Gene expression of p63 , which encodes transformation-related protein 63 (p63), was measured because it is essential for the proliferative capacity of the stem cells 11 , while the expression of Axin2 , which is a Wnt-target gene 10 , was measured to assess Wnt signalling activity in the 3D culture

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Nature 460 , 11591163 (2009)

no formal PK studies published) ~2 hours (1.3h in SBS patients

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