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10.1016/j.procbio.2004.01.001 172

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After activation of IRF3, cGAMP-bound STING oligomers are transported through the trans-Golgi and sorted into RAB7-positive late endosomes that travel to lysosomes for degradation via multivesicular bodies (141)

This chronic sympathetic activation not only causes anxiety, insomnia, and rapid heart rate, but it also signals to the innate immune system that the body is under constant threat, further provoking mast cell degranulation

Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity