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doi: 10.3390/ijms222312635 54 LiaoCYWuTCYangSFChangJT

Hippocampus mitochondrial MnSOD activation by a SIRT3 activator, honokiol, correlates with its deacetylation and upregulation of FoxO3a and PGC1 in a rat model of ammonia neurotoxicity

As a result, suffering from an insufficient amount of this nutrient can result in debilitating health effects

SOD converts superoxide to hydrogen peroxide: 2O 2 - + 2H + H 2 O 2 + O 2 The hydrogen peroxide is detoxified by the combined action of ascorbate peroxidase, dehydroascorbate reductase and glutathione reductase as mentioned in Lecture 17: Many other toxic substances taken in by organisms from the environment ( xenobiotics ) are detoxified by reaction with glutathione

(2018) 7:R21222

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