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In the STEP-1 clinical trial extension, participants regained about two-thirds of the weight they had lost within a year of stopping semaglutide

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(In literature predating structures of LPL, these residues were referred to as R75 and L225 in humans, accounting for removal of the signal sequence

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Retatrutide has not received MHRA marketing authorisation and is not available through the NHS or private prescribing in the UK

Neither medication is inherently "better" - the right choice depends on your health history, risk profile, medication tolerance, and your provider's clinical assessment