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In these studies, guinea pigs and BALB/c mice with allergic airway disease induced by ovalbumin sensitization had significantly lower total lung thiol content, with up to 40% lower GSH concentrations and threefold higher concentrations of GSSG in the lung tissue homogenate (172, 177)

With the weight of years, smoking, alcohol, treatments, physical activity, and certain diseases such as diabetes and degenerative diseases, glutathione levels in the body tend to decrease

In the United States, it affects approximately 34.6% of the people, while in Europe, the prevalence ranges from 17.8 to 34.0%

Cell Res (2023) 33:1129

Intensive study began in the 1960s due to the discovery of its functions in human body fluids

This finding emphasizes the pivotal role of HMGB1 in BUC progression