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The other twelve GST isozymes showed no mitigation effects on AFB 1 -induced toxicity, which might be due to the excessive GST activity depleting intracellular GSH so that its negative effects outweighed its weak detoxification ability [38]
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Loss of GSH synthesis induces transcription of NRF2 target genes and repression of lipogenic genes GSH synthesis is required for numerous enzymatic processes across a range of cell types in the body
Saxton, S
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