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As we age, NAD levels declineleading to fatigue, brain fog, and slower recovery

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In vitro models also evaluate cellular senescence, tracking biological mechanisms that delay apoptosis (cell death)

To predict the gene function of SERPINA12 and identify potential associations with Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways 79 , we conducted Gene Set Enrichment Analysis (GSEA 80 ,) of the RNA sequencing data from the LOBB cross-sectional cohort using CorrelationAnalyzeR (v1.0.0 81 ;)

The neuroinflammatory processes observed in obesity are similar to those seen in neurodegenerative diseases, with microglial activation, reactive astrogliosis, and insulin resistance playing key roles