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Expert Opin Ther Targets (2012) 16(9):889901

The deliberate targeting of both MC3R and MC4R ultimately culminated in the first disclosed equipotent dual agonist, 710GO

Mechanistic analysis using endocytosis pathway inhibitors indicated that PTX-CDs predominantly traverse the BBB via macropinocytosis, highlighting the involvement of energy-dependent vesicular uptake mechanisms in BBB translocation [148]

These findings are consistent with previous real-world studies conducted among people with T2DM or obesity [13, 14]

At the same time, because of their lipophilic properties, many dietary antioxidant supplements can pass through the BBB and play an important biological role in the CNS 18

Moreover, incretin-based therapies have also been proven beneficial on obesity-related comorbidities, such as knee osteoarthritis (KOA), obstructive sleep apnea (OSA) syndrome, and MASLD