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The phase 3b, open-label, randomized controlled trial enrolled 751 adults with obesity or overweight plus at least one weight-related comorbidity such as hypertension, dyslipidemia, or sleep apnea

Results from one study found that semaglutide reduced the risk of major adverse cardiovascular events, including cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke compared to a placebo

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Both compounds are subject of published peer-reviewed literature