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The risk of intestinal blockage is highest after using the medication for one and a half years, which is longer than most clinical trials for these types of drugs
Even here, the return is positive, which says something about the quality of the underlying business
In a landmark Phase 2 obesity trial, participants receiving the highest dose achieved: Up to ~24% average weight loss at 48 weeks Weight loss had not yet plateaued at the end of the study Potential for even greater reductions with longer treatment duration For context: Semaglutide (GLP-1): ~15% weight loss Tirzepatide (GIP + GLP-1): ~2123% weight loss Retatrutide (GIP + GLP-1 + Glucagon): ~24%+ weight loss in Phase 2 studies Common side effects were similar to other GLP-1based therapies and included nausea, vomiting, diarrhea, constipation, and abdominal discomfort, primarily during dose escalation
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Nat Rev Endocrinol 20(11):647660 Dosiou C, Kossler AL (2021) Thyroid eye disease: navigating the new treatment landscape
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