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Melanotan II produces melanogenesis by activation of the MC1 receptor , whereas its clinically documented sexual effects are thought to be related to its ability to activate the MC4 receptor (though the MC3 is thought to also possibly be involved)

The compound is characterized by strong receptor selectivity and a well-defined pharmacological profile, making it a useful tool for investigating GHS-R1a-mediated signal transduction and ligand-receptor interactions

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Both assays were performed with 0.1 mM NADPH and 1 U ml 1 GR

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