Participants received either 4 mg mazdutide, 6 mg mazdutide, or placebo once weekly for 48 weeks
HSA/FSA Considerations Pre-Tax Savings: Using HSA/FSA Funds: Compounded tirzepatide is HSA/FSA eligible Consultations are eligible Supplies are eligible Effectively 20-30% discount (depending on tax bracket) Cost After Tax Savings: $349/month at 25% tax bracket: Effective cost: ~$262/month Annual savings: $1,044 $349/month at 30% tax bracket: Effective cost: ~$244/month Annual savings: $1,257 Makes already affordable treatment even more accessible
Pharmacy-specific dosing
In pancreas, upon activation, GLP-1R couples to heterotrimeric G-proteins, primarily stimulating adenylyl cyclase to increase intracellular cyclic AMP (cAMP)
Overall, serum apitegromab concentrations varied over two-fold among study participants with minimal differences in total latent myostatin levels, indicating target saturation at 10 mg kg 1
Retatrutide reduces input and increases output