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The article addresses all of these under the GHK-Cu section

Dihexa has a long half-life and there are theoretical concerns of c-Met activation leading to tumorigenesis and cancer progression

10.1126/science.1135901 40 ItoS.KinoshitaS.ShiraishiN.NakagawaS.SekineS.FujimoriT.et al (2000)

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

The molecule is structurally modified with an N-terminal trans-3-hexenoyl group, which dramatically reduces its susceptibility to dipeptidyl peptidase IV (DPP-IV) degradation, the enzyme that breaks down natural GHRH

This isnt a willpower issueits biology