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These mutations impair the body's ability to convert dietary folate into its active form, which in turn severely bottlenecks the B12-dependent methionine synthase enzyme

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Dopamine multilocus genetic profile influence on reward network in chronic insomnia disorder with depression

Erythrocytes are therefore exposed to high levels of oxidative stress and at the same time possess an efficient antioxidant defense system, mainly glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase, yielding NADPH

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