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Even though it was believed that most of the immune cells and other soluble molecules cannot pass between the CNS and other organs because of BBB and it protects the CNS from inflammation caused due to pathogens access to the host, it is known that the CNS has to be regularly checked for its proper functioning to ensure the absence of any injury or damage because of some pathogen [34, 58]

S., Kim, J

Supriya Rao, M.D., a board-certified physician in internal medicine, gastroenterology, obesity medicine, and lifestyle medicine in Boston

Furthermore, both in vitro and in vivo , GLP-1 has been frequently demonstrated to reduce GI muscle activity via nerve-mediated mechanisms reliant on nitric oxide (13, 53)

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According to the UK Summary of Product Characteristics (SmPC), gastrointestinal symptoms are the most frequently reported side effects, particularly during the initial weeks of treatment