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We hypothesized that the hepatic metabolome would be similarly characterized by increased alternative energy pathway utilization, altered redox balance and glutathione depletion, and reduced levels of ATP

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Response: As stated in the CY 2026 PFS proposed rule, based on preliminary analyses of this claims-based methodology, for most Part D rebatable drugs, we expect to remove about 10 percent to 35 percent of the total number of units determined at 428.203(a) used to calculate the total rebate amount determined at 428.201(a)

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Its sequence is derived from a protective protein found naturally in stomach gastric juices