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In early disease stages, clinical changes may be subtle and challenging to capture using tools developed for evaluating interventions in later-stage patients (Boxer and Sperling, 2023)

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This can include infusions, steroids, or surgeries

Zinman, B., Bhosekar, V., Busch, R., Holst, I., Ludvik, B., Thielke, D

By applying high-frequency oscillations directly to the regolith interface, the system induces a liquefaction-like state in the top layer of soil, allowing particles to reorient into a more densely packed configuration during transit

The dose was increased by 2.5 mg every four weeks until reaching the appropriate amount