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B12 deficiency is most common in individuals with conditions like pernicious anemia, certain gastrointestinal disorders (such as Crohns disease or celiac disease), or those who have had gastric surgery

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In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor

Despite the significance of this method in measuring solid stress in vivo, its clinical applicability is hindered by the need for intravital window implantation