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Exogenous insulin may be needed for individuals with diabetes mellitus, in whom there is a deficiency in endogenous insulin or increased insulin resistance

For now, the take-home messages for an informed patient or provider are: GLP-1 RAs (Ozempic, Wegovy, Mounjaro, etc.) are highly effective for T2D and obesity, offering glycemic control and substantial weight loss along with protective effects on the heart and possibly kidneys

GIPR: glucose-dependent insulinotropic polypeptide receptor

What natural methods cannot do is remove significant hanging skin, which is a structural change rather than a surface one

The FDA does not review them for safety, effectiveness, or quality before marketing

This article was reviewed by Craig Primack, MD, FACP, FAAP, FOMA