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Important: Retatrutide is currently an investigational medication and has not been approved by the U.S

Clinical trials including STEP 14 and SURMOUNT 14 demonstrated GLP-1 efficacy but also showed dose-dependent side effects requiring titration under medical supervision

Safety First Patients receive instructions regarding administration, storage, side effects and when to contact the medical team

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Meta-analyses of randomized, controlled trials of testosterone replacement therapy report conflicting findings , probably because the included trials lacked power or the duration was too short to assess cardiovascular events