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The commenter noted that this timeline aligns with the MIPS review process and could help address the limitations of conducting a thorough review under the proposed 30-day window

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Using 1.00mm needles: Once every 3 to 4 weeks

At the end of the experiment, animals were anesthetized with ketamine (87 mg/kg) and xylazine (13 mg/kg) before sacrifice by cervical dislocation in accordance with ethical guidelines 64

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