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While some providers recommend brushing before dosing to prepare the mucosa, aggressive brushing can actually cause bleeding or irritation that changes absorption patterns

Lancet Neurol (2015) 14(9):94555

The most frequent side effects are nausea and diarrhea

And to combat some of those muscle losses, I think is really important that we incorporate strength training as part of diet, sleep, exercise, lifestyle, but then also to help improve their, again, metabolic burn, but also minimize some of those side effects from the GLP-1