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Expression reconstitution with wild-type IRE1, but not the IRE1 K907A mutant reduced GSH levels to that of the wild-type control cells, suggesting that the RNase function of IRE1 is responsible for regulating GSH levels (Fig

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Big picture (evidence base)

Tea, the cacao in chocolate, red wine, red onions, olives and all the blueish berries are rich sources of polyphenols

As a thiol-containing compound, GSH is particularly susceptible to oxidation upon exposure to air, light, and elevated temperatures