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Case 1: A 45-Year-Old Woman A 45-year-old woman with CSU since 2019 had persistent symptoms despite the use of up to four tablets of rupatadine (10 mg) daily (UAS7 1418 on rupatadine)

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Colitis occurs more commonly with ipilimumab and with CICB than with anti-PD-1/PD-L1 mAbs alone (120, 131)

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Results We used the GSH/GSSG-Glo Assay to monitor GSH and GSSG levels and observe the oxidative stress in adherent HEK-293 cells and suspension K-562 cells dosed with menadione (Figures 3 and 4)