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Comparing efficacy on the basis of preclinical 5-Amino-1MQ data would be misleading
Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)
Metabolic support (glucose control, strength training, zone-2 conditioning when appropriate)
This mechanism further establishes SFN as a multi-valent epigenetic modulator with broad therapeutic potential
This promising and attractive combination strategy is currently being evaluated in multiple clinical trials (NCT04343157, NCT04073966)