Immunohistochemistry of liver sections showed CD36 as located in the hepatocyte plasma membrane in patients with steatosis and NASH, compared to a weak CD36 expression confined to the cytoplasm of hepatocytes in normal livers, suggesting that the translocation of CD36 protein from cytoplasm to membrane may be a triggering event in NAFLD progression [25]
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Patients report better control over blood sugar levels, reduced blood pressure, improved cholesterol profiles, and decreased markers of inflammation
The SELECT trial (2023) demonstrated a 20% reduction in major adverse cardiovascular events in non-diabetic obese patients establishing cardiovascular research as a major frontier for GLP-1 agonist compounds
JAMA Cardiology 2022, 7: 857-865
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