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The molecule has been modified to stay active in the body longer

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These rates compare favorably with the Phase 2 discontinuation rates (10-17%), likely reflecting the improved dose-escalation schedules used in Phase 3

Then, a system in your body that regulates blood pressure gets activated, causing your kidneys to hold on to more water and salt

3) There is a risk you will overdose if we give it too early (the GP)

The most well-established microvascular diseases and disorders include diabetic microvascular complications, small cerebral vessel disease, renal microvascular disease, pulmonary microvascular disease, systemic autoimmune microvascular disorders, and hereditary microangiopathies [155158]