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Of course, whenever youre activating GLP-1 receptors in the hypothalamus to suppress appetite, youre also activating the same receptors in the area postrema, which mediates some of the nausea and GI symptom formation, so thats still there

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Hantson P, Grandin C, Duprez T, Nassogne MC, Gurit JM: Comparison of clinical, magnetic resonance and evoked potentials data in a case of valproic-acid-related hyperammonemic coma