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Lower concentrations allow for easier volume measurement when beginning therapy, while higher concentrations reduce injection volume as patients advance to maintenance doses

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In one study of children ages 10 months to 4 years, it was found that APAP lowered the fevers of some children with febrile seizure and a temperature above 38.5 o C more effectively than it lowered the fevers of other children ( APAP PHARMACOKINETICS IN CHILDREN As has been observed with many other drugs, the variability in APAP PK varies with age from birth to adulthood

These variants affect receptor sensitivity and signaling efficiency, potentially shaping the onset and duration of diarrhea