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Ethics declarations Ethics approval and consent to participate This study was conducted in compliance with the ethical principles of the Declaration of Helsinki

CVD includes heart disease, heart failure, stroke, and peripheral arterial disease

Human Evidence: What We Know (and Dont) Controlled clinical trials specifically on 5-Amino-1MQ are limited

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Animals 11 , 19 (2021)

184,185,203 It is important to note that because most PK-deficient patients are compound heterozygous for two different (missense) mutations, up to seven different tetrameric forms of PK may be present in such patients, each with distinct structural and kinetic properties