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According to the National Institute of Mental Health (NIMH), CBT has been shown to be highly effective, with studies indicating that 60-80% of patients with anxiety and depression show improvement after CBT

Specifically, the deletion of TrkB in iSPNs elevated the expression of Gsto2 , thereby leading to increased dopamine levels through alterations of ascorbic acid homeostasis and disruption of energy metabolism in the neurons

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Exploratory endpoints included achieving 15% and 20% weight loss, and patient-reported outcomes assessed using the SF-36 v2.0 and the Three-Factor Eating Questionnaire (TFEQ-R18 v2)