Histamine Histamine, a potent biogenic amine, serves as a pivotal chemical messenger linking gastrointestinal dysfunction to peripheral pathologies, particularly laminitis, in dairy cows
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10,14 The light, modifier subunit provides a regulatory function, while GCLC is responsible for the catalytic activity, which conjugates sulfur-containing cysteine with glutamate, forming -glutamylcysteine
8, 9, 10, 11, 12 these patients and experimental animals have a diminished antioxidant status, 13 which contributes to the accumulating evidence that increased vascular oxidative stress could be involved in the pathogenesis of essential hypertension