Studies show that without ongoing medication: Most patients regain 75-90% of lost weight within two years Many report unusually strong hunger signals after discontinuation Metabolic adaptation makes weight maintenance significantly more challenging Of all the potential long-term effects, bone health deserves special attention because: Bone loss occurs silently : Unlike digestive side effects that are immediately noticeable, bone loss happens gradually with no symptoms until a fracture occurs The effects can be permanent : Once significant bone loss occurs, it can be difficult to fully restore The consequences are serious : Osteoporotic fractures can lead to chronic pain, disability, and in the case of hip fractures, a 20-30% mortality rate in the first year Combination risk factors : Many people taking GLP-1 medications already have other risk factors for osteoporosis, creating a perfect storm for bone health problems Also read: Does Ozempic Cause Osteoporosis

This provides us with a comprehensive view, not just a snapshot, of your health
This is the mechanism that drives weight loss
Tanaka M, Matsuo Y, Yamakage H, Masuda S, Terada Y, Muranaka K, Wada H, Hasegawa K, Shimatsu A, Satoh-Asahara N
Go to the emergency room or urgent care if you experience: Your vomiting and diarrhea are severe Have signs of dehydration such as dizziness, extreme thirst, are peeing infrequently or have dark pee Significant abdominal pain that happens suddenly Have blood in your stool or vomit The Bottom Line GLP-1 medications can offer significant improvements in health, but they may not be suitable for everyone
Diabetes Care 33 , 16071609 (2010)