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Excretion Pathways Limited data on combined excretion indicates: Primarily renal elimination of peptide fragments Hepatic metabolism contributes to overall clearance Copper recycling through normal physiological pathways No evidence of accumulation in chronic dosing studies (animal models) The relationship between rapid plasma clearance and prolonged biological effects represents a key area requiring further mechanistic investigation across all three components

10.1074/jbc.271.9.4653 J

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But if youre running multiple copper-containing compounds or high-dose protocols, total Cu 2+ exposure needs to be tracked

That said, our experts emphasize that formulation matters more than originL-ascorbic acid is still the most well-studied form of vitamin C, so its always worth looking at the ingredient list