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Importantly, overexpression of the YAP mutant (YAP-5SA) attenuates the inhibition of metformin on the stem and epithelial-mesenchymal transformation of glioma cells

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Complementary defense systems include the FSP1-coenzyme Q (CoQ) axis and the GTP cyclohydrolase 1-tetrahydrobiopterin (GCH1-BH4) pathway, both of which suppress lipid peroxidation independently of GPX4 (30)(31)(32)

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The GstA1 gene, which encodes a 29 kD GST protein (GST29) was specifically inducible by fungal infections and exogenous GSH, but not by various xenobiotics that typically induce GST activity (paraquat, atrazine, alachlor, metolachlor) (Mauch and Dudler, 1993)