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It is widely recognised that metformin improves glycaemic control with a good safety profile, weight neutrality or weight loss, lack of associated hypoglycaemia, reduced cardiovascular mortality and low cost [3]

However, other studies found that the inactive forms were effective

Clin Transl Sci 15(5):11671186 Pontes-da-Silva RM, de Souza MT, de Macedo Cardoso LE, Mandarim-de-Lacerda CA, Aguila MB (2022) Obese mice weight loss role on nonalcoholic fatty liver disease and endoplasmic reticulum stress treated by a GLP-1 receptor agonist

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Beyond mitochondrial mechanisms, L-carnitine inhibits hepatocyte autophagy and apoptosis

Improves Organ Function: Preclinical studies suggest improved organ function due to age-related decline